(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol → 4-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde

HRID 875969

反応式

HRID 875969 の反応式
[Cl:1][C:2]1[C:7]([CH2:8][OH:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1>C(Cl)(Cl)Cl.[O-2].[Mn+4].[O-2]>[Cl:1][C:2]1[C:7]([CH:8]=[O:9])=[CH:6][N:5]=[C:4]([S:10][CH3:11])[N:3]=1

参加物

4

反応物 1

HCID 59419388(4-Chloro-2-(methylthio)pyrimidin-5-yl)methanol

生成物 1

HCID 594193864-Chloro-2-(methylsulfanyl)pyrimidine-5-carbaldehyde収率 82.8%

試薬・触媒・溶媒 2

HCID 178418406HCID 178418406、化合物触媒HCID 6212Chloroform溶媒

実験手順

Manganese(IV) oxide, <5 micron, activated (38.1 g, 439 mmol) was added to a solution of compound 223 (16.73 g, 87.8 mmol) in chloroform (800 mL). The reaction was stirred overnight, filtered through Celite, and the filtrate was concentrated in vacuo to yield compound 224 (13.7 g, 82.8% yield). 1H NMR (500 MHz, CDCl3) δ 10.31 (s, 1 H) 8.88 (s, 1 H) 2.65 (s, 2 H) ppm.

後処理

  1. filtrationfiltered through Celite
  2. concentrationthe filtrate was concentrated in vacuo

出典と根拠

ORDレコード
ord-9062d7f97d35471c88edfc07bb16b9d5
出典データセット
uspto-grants-2015_03
特許番号
US08980903B2

関連ノート

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