3-Acetyl-5-bromo-2-hydroxybenzoic acid → 3-Acetyl-2-hydroxybenzoic acid

HRID 876535ノート

反応式

HRID 876535 の反応式
[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[C:11](Br)[CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]>C(O)C.[Pd]>[C:1]([C:4]1[C:5]([OH:14])=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([OH:9])=[O:8])(=[O:3])[CH3:2]

参加物

4

反応物 1

HCID 110106863-Acetyl-5-bromo-2-hydroxybenzoic acid

生成物 1

HCID 108992643-Acetyl-2-hydroxybenzoic acid収率 85%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 702Ethanol溶媒

実験手順

3-acetyl-5-bromo-2-hydroxybenzoic acid 31 (50 g, 0.19 mol) was dissolved in 250 mL ethanol. After addition of 5.0 g 10% Pd/C the reaction mixture was hydrogenated under 15 atm H2-pressure at room temperature for 6 h. The catalyst was filtered and the solvent was evaporated. The residue was poured into H2O and extracted with CH2Cl2. The combined organic phase was dried and the solvent was removed to give 32 (28 g, 85% yield)

後処理

  1. filtrationThe catalyst was filtered
  2. customthe solvent was evaporated
  3. additionThe residue was poured into H2O
  4. extractionextracted with CH2Cl2
  5. customThe combined organic phase was dried
  6. customthe solvent was removed

出典と根拠

ORDレコード
ord-43d3767f31fd48d9ab13f969cd83fe22
出典データセット
uspto-grants-2015_03
特許番号
US08987258B2

反応ノート

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