Water → HCID 15123266、化合物

HRID 876551ノート

反応式

HRID 876551 の反応式
C([O-])([O-])=O.[K+].[K+].Cl[CH2:8][C:9]1[N:14]=[C:13]([C:15]([O:17][CH3:18])=[O:16])[CH:12]=[CH:11][CH:10]=1.[NH:19]1[CH2:23][CH2:22][CH2:21][CH2:20]1.O>CN(C=O)C>[N:19]1([CH2:8][C:9]2[N:14]=[C:13]([C:15]([O:17][CH3:18])=[O:16])[CH:12]=[CH:11][CH:10]=2)[CH2:23][CH2:22][CH2:21][CH2:20]1

参加物

6

反応物 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 31268PyrrolidineHCID 53404482Methyl 6-(chloromethyl)pyridine-2-carboxylate

生成物 1

HCID 15123266HCID 15123266、化合物収率 67.4%

試薬・触媒・溶媒 1

HCID 6228Dimethylformamide溶媒

反応条件

温度
80 °C

実験手順

K2CO3 (66 g, 0.48 mol) was added to a solution of methyl 6-(chloromethyl)picolinate 71 (45.0 g) and pyrrolidine 72 (34 g, 0.48 mol) in DMF (300 mL). The reaction mixture was heated at 80° C. for 12 h. H2O (300 mL) was added and the mixture was extracted with EtOAc. The combined organic layers were washed with brine, dried (Na2SO4) and concentrated in vacuo to give 73 (36 g).

後処理

  1. extractionthe mixture was extracted with EtOAc
  2. washThe combined organic layers were washed with brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-4bd2e1c68df848a588d9c270987f3432
出典データセット
uspto-grants-2015_03
特許番号
US08987258B2

反応ノート

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