Sodium Hydroxide → 1-(6-Chloropyrimidin-4-yl)azetidin-3-ol

HRID 876659ノート

反応式

HRID 876659 の反応式
Cl[C:2]1[N:7]=[C:6]([Cl:8])[CH:5]=[CH:4][N:3]=1.Cl.[OH:10][CH:11]1[CH2:14][NH:13][CH2:12]1.[OH-].[Na+]>O>[Cl:8][C:6]1[N:7]=[CH:2][N:3]=[C:4]([N:13]2[CH2:14][CH:11]([OH:10])[CH2:12]2)[CH:5]=1

参加物

5

反応物 3

HCID 14798Sodium HydroxideHCID 775312,4-Dichloropyrimidine2 回HCID 27592903-Hydroxyazetidine hydrochloride

生成物 1

HCID 579250791-(6-Chloropyrimidin-4-yl)azetidin-3-ol収率 115.1%

試薬・触媒・溶媒 1

HCID 962Water溶媒

実験手順

7.2 g (48.7 mmol) 2,4-dichloropyrimidine are initially introduced into 140 ml water. 5.3 g (48.7 mmol) 3-hydroxyazetidine hydrochloride and 48.7 ml 1 N sodium hydroxide solution are added and the mixture is heated at 90° C. for 72 h (the 2,4-dichloropyrimidine being detectably volatile and precipitating in crystalline form on the condenser). The solvent is removed in vacuo and the residue is dried to give 10.4 g of the crude product, which is reacted without further purification.

後処理

  1. customprecipitating in crystalline form on the condenser)
  2. customThe solvent is removed in vacuo
  3. customthe residue is dried

出典と根拠

ORDレコード
ord-5b075ba59a9b4b8082cb1b5a68c371b8
出典データセット
uspto-grants-2015_03
特許番号
US08987261B2

反応ノート

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