Aluminium lithium hydride → Thieno[3,2-c]pyridin-2-ylmethanol

HRID 876767ノート

反応式

HRID 876767 の反応式
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[C:10](OC)=[O:11].[H-].[H-].[H-].[H-].[Li+].[Al+3]>C1COCC1>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[CH:3]=[C:2]1[CH2:10][OH:11]

参加物

4

反応物 2

HCID 21226445Aluminium lithium hydrideHCID 22047666Methyl thieno[3,2-c]pyridine-2-carboxylate

生成物 1

HCID 46784992Thieno[3,2-c]pyridin-2-ylmethanol

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
0 °C

実験手順

To a solution of methyl thieno[3,2-c]pyridine-2-carboxylate (D-2) (15 g, 77.6 mmol) in anhydrous THF (250 mL) was added LiAlH4 (4.42 g, 116.4 mmol) in portions at 0° C. The suspension was stirred at 0° C. for 1 h and then quenched by adding saturated aqueous NH4Cl and filtered. The filtrate was washed with brine and concentrated. The residue was used in the next step without any further purification (10.3 g).

後処理

  1. customquenched
  2. additionby adding saturated aqueous NH4Cl
  3. filtrationfiltered
  4. washThe filtrate was washed with brine
  5. concentrationconcentrated
  6. customThe residue was used in the next step without any further purification (10.3 g)

出典と根拠

ORDレコード
ord-6b7c4c9efd8e46a58e4caeac72e0c018
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

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