反応式
[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]([NH2:13])=O)=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.C(N(CC)CC)C.FC(F)(F)C(OC(=O)C(F)(F)F)=O>C(Cl)Cl>[N:1]1[C:10]2[C:5](=[CH:6][C:7]([C:11]#[N:13])=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1参加物
5
反応条件
- 温度
- 0 °C
実験手順
To a mixture of quinoline-6-carboxamide (0-3) (1.2 g, 7.2 mmol) and triethylamine (2.2 g, 21.8 mmol) in DCM (50 mL) at 0° C. was added trifluoroacetic acid anhydride (1.9 g, 8.9 mmol). The reaction was stirred for 10 mins at 0° C., then quenched with water. The resulting mixture was extracted with DCM. The organic layer was dried over anhydrous Na2SO4, and concentrated to afford the desired title compound (1.0 g). MS (m/z): 154 (M)+.
後処理
- customquenched with water
- extractionThe resulting mixture was extracted with DCM
- dry with materialThe organic layer was dried over anhydrous Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-afe968d3ef0340db91325a91e1947b50
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987269B2
関連ノート
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