Sodium borohydride → Thiazolo[4,5-c]pyridin-2-ylmethanol

HRID 876801ノート

反応式

HRID 876801 の反応式
[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[C:2]1[C:10](OCC)=[O:11].[BH4-].[Na+]>C(O)C>[S:1]1[C:9]2[CH:8]=[CH:7][N:6]=[CH:5][C:4]=2[N:3]=[C:2]1[CH2:10][OH:11]

参加物

4

反応物 2

HCID 4311764Sodium borohydrideHCID 65583458Ethyl thiazolo[4,5-c]pyridine-2-carboxylate

生成物 1

HCID 55296405Thiazolo[4,5-c]pyridin-2-ylmethanol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

To a solution of ethyl thiazolo[4,5-c]pyridine-2-carboxylate (R-3) (5 g, 24 mmol) in ethanol (100 mL) was added NaBH4 (0.9 g, 24 mmol) in portions at 0° C. The suspension was stirred at room temperature for 1 h, and then concentrated. The resulting residue was dissolved in EtOAc, washed with water. The organic layer was separated, dried over Na2SO4, concentrated in vacuo and purified by chromatography on silica gel to give the title compound. MS (m/z): 167 (M+1)+.

後処理

  1. concentrationconcentrated
  2. dissolutionThe resulting residue was dissolved in EtOAc
  3. washwashed with water
  4. customThe organic layer was separated
  5. dry with materialdried over Na2SO4
  6. concentrationconcentrated in vacuo
  7. custompurified by chromatography on silica gel

出典と根拠

ORDレコード
ord-0e902d08eb0543d48737ba84b67a22d6
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

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