Sodium borohydride → Imidazo[1,2-b]pyridazin-6-ylmethanol
反応式
[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([C:10](OC)=[O:11])=[N:5]2.[BH4-].[Na+]>C(O)C>[N:1]1[CH:2]=[CH:3][N:4]2[C:9]=1[CH:8]=[CH:7][C:6]([CH2:10][OH:11])=[N:5]2参加物
4
実験手順
To a solution of methyl imidazo[1,2-b]pyridazine-6-carboxylate (1-3) (891 mg, 5.03 mmol) in ethanol (25 mL) was added NaBH4 (420 mg, 11.1 mmol) at room temperature. The suspension was stirred at room temperature for 2 h. The reaction mixture was concentrated in vacuum. The residue was purified by chromatography on silica gel to afford the title compound (630 mg). MS (m/z): 150 (M+1)+
後処理
- concentrationThe reaction mixture was concentrated in vacuum
- customThe residue was purified by chromatography on silica gel
出典と根拠
- ORDレコード
- ord-dedf1f7be56c484f8cb522ca99d6064e
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987269B2
反応ノート
読み込み中…