N-(6-chloro-3-nitro-2-(quinolin-6-ylmethylamino)pyridin-4-yl)acetamide → N-(3-Amino-6-chloro-2-(quinolin-6-ylmethylamino)pyridin-4-yl)acetamide

HRID 876848ノート

反応式

HRID 876848 の反応式
[Cl:1][C:2]1[N:7]=[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)[C:5]([N+:20]([O-])=O)=[C:4]([NH:23][C:24](=[O:26])[CH3:25])[CH:3]=1>CO.C(Cl)Cl.[Pd]>[NH2:20][C:5]1[C:6]([NH:8][CH2:9][C:10]2[CH:11]=[C:12]3[C:17](=[CH:18][CH:19]=2)[N:16]=[CH:15][CH:14]=[CH:13]3)=[N:7][C:2]([Cl:1])=[CH:3][C:4]=1[NH:23][C:24](=[O:26])[CH3:25]

参加物

5

反応物 1

HCID 86671444N-(6-chloro-3-nitro-2-(quinolin-6-ylmethylamino)pyridin-4-yl)acetamide

生成物 1

HCID 86671445N-(3-Amino-6-chloro-2-(quinolin-6-ylmethylamino)pyridin-4-yl)acetamide

試薬・触媒・溶媒 3

HCID 23938Palladium触媒HCID 887Methanol溶媒HCID 6344Dichloromethane溶媒

実験手順

To a solution of N-(6-chloro-3-nitro-2-(quinolin-6-ylmethylamino)pyridin-4-yl)acetamide (220 mg, 0.593 mmol) in methanol (5 mL) and CH2Cl2(5 mL) was added 10% catalytical amount Pd/C. The reaction mixture was stirred at room temperature under 1 atm of H2 for 1 h, then filtered. The filtrate was concentrated to afford the title compound, which was used for the next step without further purification. MS (m/z): 342 (M+1)+.

後処理

  1. filtrationfiltered
  2. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-7fdc9ad41fa545e4acc6c56cca329be9
出典データセット
uspto-grants-2015_03
特許番号
US08987269B2

反応ノート

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