Benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate → 1-[(Dimethylphosphoryl)methyl]piperazine
反応式
[CH3:1][P:2]([CH2:5][N:6]1[CH2:11][CH2:10][N:9](C(OCC2C=CC=CC=2)=O)[CH2:8][CH2:7]1)([CH3:4])=[O:3]>[Pd].CO>[CH3:4][P:2]([CH2:5][N:6]1[CH2:7][CH2:8][NH:9][CH2:10][CH2:11]1)([CH3:1])=[O:3]参加物
4
実験手順
To a flask was charged with benzyl 4-((dimethylphosphinoyl)methyl)piperazine-1-carboxylate (200 mg) and 10% palladium on carbon in methanol (20 mL). The mixture was stirred at room temperature under H2 atmosphere. The mixture was filtered through Celite and all solvents were removed under reduced pressure to give a white crystalline solid, which was used without further purification. LCMS ESI(+) m/z: 177 (M+1).
後処理
- filtrationThe mixture was filtered through Celite
- customall solvents were removed under reduced pressure
- customto give a white crystalline solid, which
- customwas used without further purification
出典と根拠
- ORDレコード
- ord-3433a2443b704798bda5efe04195b433
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987284B2
反応ノート
読み込み中…