Chloroacetyl chloride → N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide

HRID 877153

反応式

HRID 877153 の反応式
[CH3:1][C:2]([CH3:8])([CH3:7])[C:3]([NH:5][NH2:6])=[O:4].[Cl:9][CH2:10][C:11](Cl)=[O:12]>C(OCC)(=O)C>[Cl:9][CH2:10][C:11]([NH:6][NH:5][C:3](=[O:4])[C:2]([CH3:8])([CH3:7])[CH3:1])=[O:12]

参加物

4

反応物 2

HCID 6577Chloroacetyl chlorideHCID 5451472,2-Dimethylpropanehydrazide

生成物 1

HCID 54595759N'-(2-chloroacetyl)-2,2-dimethylpropanehydrazide

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒2 回

実験手順

5.8 g (49.929 mmol) of 2,2-dimethylpropanehydrazide were dissolved in 600 ml of dry ethyl acetate and heated to reflux. 6.767 g (59.915 mmol) of chloroacetyl chloride, dissolved in 45 ml of dry ethyl acetate, were added dropwise to the solution. The mixture was stirred under reflux for 30 min. After cooling, the reaction mixture was concentrated on a rotary evaporator and the residue was dried under high vacuum. This gave 10.14 g of the title compound. The crude product was reacted further without further purification.

後処理

  1. temperatureheated to reflux
  2. additionwere added dropwise to the solution
  3. temperatureunder reflux for 30 min
  4. temperatureAfter cooling
  5. concentrationthe reaction mixture was concentrated on a rotary evaporator
  6. customthe residue was dried under high vacuum
  7. customThe crude product was reacted further without further purification

出典と根拠

ORDレコード
ord-5de56236fbe84fa7b3bc245c0078ba42
出典データセット
uspto-grants-2015_03
特許番号
US08987256B2

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