Methanol → HCID 66893992、化合物

HRID 877172ノート

反応式

HRID 877172 の反応式
S(Cl)([Cl:3])=O.[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([OH:16])=[O:15])[CH2:7]1.[CH3:17]O>>[ClH:3].[NH2:5][CH:6]1[CH2:11][CH2:10][CH2:9][CH:8]([CH2:12][CH2:13][C:14]([O:16][CH3:17])=[O:15])[CH2:7]1

参加物

4

反応物 3

HCID 887MethanolHCID 24386Thionyl ChlorideHCID 4523697HCID 4523697、化合物

生成物 1

HCID 66893992HCID 66893992、化合物

実験手順

At −5° C., 1.9 ml (25.7 mmol) of thionyl chloride were slowly added dropwise to 50 ml of methanol, and the mixture was stirred at this temperature for 10 min. 2 g (11.7 mmol) of 3-(3-aminocyclohexyl)propanoic acid were then added in one portion, and the reaction mixture was stirred at room temperature overnight. After the reaction had gone to completion, the solvent was evaporated under reduced pressure. This gave 2.46 g (11.1 mmol, 95% of theory) of a colorless solid.

後処理

  1. stirringthe reaction mixture was stirred at room temperature overnight
  2. customthe solvent was evaporated under reduced pressure

出典と根拠

ORDレコード
ord-3478c03fd6ab48f4887030b5cfc5ba15
出典データセット
uspto-grants-2015_03
特許番号
US08987256B2

反応ノート

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