Methanol → 2-(1,1-Dimethoxyethyl)thiazole
反応式
[S:1]1[CH:5]=[CH:4][N:3]=[C:2]1[C:6](=[O:8])[CH3:7].[CH3:9]C1C=CC(S(O)(=O)=O)=CC=1.[CH3:20][OH:21]>>[CH3:20][O:21][C:6]([C:2]1[S:1][CH:5]=[CH:4][N:3]=1)([O:8][CH3:9])[CH3:7]参加物
4
実験手順
A mixture of 1-(1,3-thiazol-2-yl)ethanone (35 g, 0.28 mol), anhydrous p-TsOH (50 g, 0.29 mol) and trimethyl ortheformate (175 ml) in methanol (500 ml) was refluxed for 18 h. After concentration, the residue was partitioned between sat. NaHCO3 and ether. The organic layers were washed with brine, dried over Na2SO4 and concentrated to give 36 g (75.6%) of 2-(1,1-dimethoxyethyl)-1,3-thiazole as an oil.
後処理
- temperaturewas refluxed for 18 h
- concentrationAfter concentration
- customthe residue was partitioned between sat. NaHCO3 and ether
- washThe organic layers were washed with brine
- dry with materialdried over Na2SO4
- concentrationconcentrated
出典と根拠
- ORDレコード
- ord-fb2a5368ff824a90b196b2e33722bc00
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987310B2
反応ノート
読み込み中…