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Diisopropylethylamine → HCID 60197099、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 3-Chloro-4-fluorobenzoyl Chloride | HCID 2736548 | — |
| 反応物 | N-methyl-4-o-tolylpyridin-3-amine | HCID 18403336 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | HCID 60197099 | HCID 60197099 | 29% |
反応手順
3-Chloro-4-fluorobenzoyl chloride (60 mg, 0.31 mmol, CAS RN 65055-17-6) was added to a solution of methyl-(4-o-tolyl-pyridin-3-yl)-amine (45 mg, 0.23 mmol, example 1, intermediate a) and DIPEA (79 μL, 0.45 mmol) in CH2Cl2 (1 mL). The reaction mixture was stirred overnight and then loaded directly onto a silica gel column and eluted with 50% EtOAc in n-hexane to yield the product as a waxy solid (23 mg, 29%). MS (ESI): m/z=355.0 [M+H]+.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08987307B2 |
| 出典データセット | uspto-grants-2015_03 |
| ORD ID | ord-3d1e2f56dcde4ff895a1a1fa88d547c7 |
| 出典メモ | uspto-grants-2015_03 |