Methyl iodide → (2-Chloro-4-iodo-pyridin-3-yl)-methyl-carbamic acid tert-butyl ester

HRID 878243ノート

反応式

HRID 878243 の反応式
Cl[C:2]1C=CC=CC=1C1C=CN=CC=1N(CCS(C)(=O)=O)C(=O)C1C=C(C(F)(F)F)C=C(C(F)(F)F)C=1.[C:37]([O:41][C:42](=[O:52])[NH:43][C:44]1[C:45]([Cl:51])=[N:46][CH:47]=[CH:48][C:49]=1[I:50])([CH3:40])([CH3:39])[CH3:38].CI>CCCCCCC.CCOC(C)=O>[C:37]([O:41][C:42](=[O:52])[N:43]([C:44]1[C:45]([Cl:51])=[N:46][CH:47]=[CH:48][C:49]=1[I:50])[CH3:2])([CH3:40])([CH3:38])[CH3:39]

参加物

5

反応物 3

HCID 6328Methyl iodideHCID 24229170(2-Chloro-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl esterHCID 86670734N-[4-(2-Chloro-phenyl)-pyridin-3-yl]-N-(2-methanesulfonyl-ethyl)-3,5-bis-trifluoromethyl-benzamide

生成物 1

HCID 86670802(2-Chloro-4-iodo-pyridin-3-yl)-methyl-carbamic acid tert-butyl ester

試薬・触媒・溶媒 1

HCID 21899848Ethylacetate heptane溶媒

実験手順

The title compound was prepared in analogy to example 85, intermediate c, from (2-chloro-4-iodo-pyridin-3-yl)-carbamic acid tert-butyl ester (CAS RN 855784-39-3) and methyl iodide and using a gradient of n-heptane:EtOAc (100:0 to 50:50) for the chromatographic purification. Colorless solid (88%). MS (ESI): m/z=368.99 [M+H]+.

後処理

  1. customfor the chromatographic purification

出典と根拠

ORDレコード
ord-a3f642eabe7a4cfdaf15a594f86d1a9a
出典データセット
uspto-grants-2015_03
特許番号
US08987307B2

反応ノート

読み込み中…