(2-Nitrophenyl)hydrazine → HCID 178517309、化合物

HRID 878791

反応式

HRID 878791 の反応式
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][S:8]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=O)(=[O:10])=[O:9].[N+:22]([C:25]1[CH:30]=[CH:29][CH:28]=[CH:27][C:26]=1[NH:31][NH2:32])([O-:24])=[O:23]>Cl.C(O)C>[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[CH2:6][NH:7][S:8]([C:11]1[CH:12]=[C:13]2[C:17](=[CH:18][CH:19]=1)[NH:16][C:15](=[O:20])[C:14]2=[N:32][NH:31][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][C:25]=1[N+:22]([O-:24])=[O:23])(=[O:10])=[O:9]

参加物

5

反応物 2

HCID 3314739(2-Nitrophenyl)hydrazineHCID 59763031HCID 59763031、化合物

生成物 1

HCID 178517309HCID 178517309、化合物

試薬・触媒・溶媒 2

HCID 313Hydrochloric Acid触媒HCID 702Ethanol溶媒

反応条件

温度
120 °C

実験手順

A mixture of rpm161 (0.040 g, 0.114 mmol) 2-nitrophenylhydrazine (0.021 g, 0.126 mmol, 1.1 eq) and HCl (aq 4 M, 2 drops) in ethanol (3 mL) was heated in the CEM microwave at 120° C. for 15 min. After cooling to room temperature, pure product rpm168 was collected as an orange precipitate by filtration and dried in vacuo. The pure compound rpm168 was obtained without further purification (0.048 g, 0.099 mmol, 86%). MS (API-ES): m/z 459 (M+NH4)+; HRMS (API-ES) m/z Found: 459.1082 (M+NH4)+.

後処理

  1. temperatureAfter cooling to room temperature
  2. filtrationwas collected as an orange precipitate by filtration
  3. customdried in vacuo
  4. customwas obtained without further purification (0.048 g, 0.099 mmol, 86%)

出典と根拠

ORDレコード
ord-3013d6af1a784f6da467cae0cdc17c3c
出典データセット
uspto-grants-2015_03
特許番号
US08987474B2

関連ノート

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