1,4-Butanediol → 4-Hydroxybutyl ethyl(2-hydroxyethyl)phosphinate
反応式
[CH2:1]([P:3]([CH2:6][CH2:7][OH:8])(=[O:5])[OH:4])[CH3:2].[CH2:9](O)[CH2:10][CH2:11][CH2:12][OH:13]>C1(C)C=CC=CC=1>[CH2:1]([P:3]([CH2:6][CH2:7][OH:8])(=[O:4])[O:5][CH2:9][CH2:10][CH2:11][CH2:12][OH:13])[CH3:2]参加物
4
実験手順
414 g (3.0 mol) of ethyl(2-hydroxyethyl)phosphinic acid (produced as in Example 7) are at 80° C. dissolved in 400 ml of toluene and admixed with 594 g (6.6 mol) of 1,4-butanediol and esterified at about 100° C. in a distillation apparatus equipped with water trap during 4 h. On completion of the esterification the toluene is removed in vacuo to leave 504 g (80% of theory) of 4-hydroxybutyl ethyl-(2-hydroxyethyl)phosphinate as colorless oil.
後処理
- customare at 80° C.
- customesterified at about 100° C. in a distillation apparatus
- customequipped with water trap during 4 h
- customOn completion of the esterification the toluene is removed in vacuo
出典と根拠
- ORDレコード
- ord-09c8d1a88b6a4a08aac37aa96134fb0e
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987490B2
反応ノート
読み込み中…