Hydrogen Peroxide → 2,3-Epoxy-2-methyl-1,4-naphthoquinone
反応式
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[OH-:14].[Na+].OO>CO.O>[CH3:1][C:2]12[C:12](=[O:13])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4](=[O:5])[CH:3]1[O:14]2参加物
5
実験手順
Menadione crystalline (1) (5 g, 29.04 mmol, 1 equivalent) and 2 M NaOH (7.26 mL, 14.52 mmol, 0.5 equivalents) are dissolved in a mixture of methanol/water 4:1 (50 mL) at 0-2° C. After stirring at this temperature for 10 minutes, 35% hydrogen peroxide is added (4.2 mL, 43.56 mmol, 1.5 equivalents). Work-up: after 30 minutes at 0° C. the product is extracted with ethyl ether. The organic phase is dried over Na2SO4 and evaporated under reduced pressure. A whitish powder is obtained (5 g, 26.57 mmol). Yield: 91.5%.
後処理
- extractionafter 30 minutes at 0° C. the product is extracted with ethyl ether
- dry with materialThe organic phase is dried over Na2SO4
- customevaporated under reduced pressure
- customA whitish powder is obtained (5 g, 26.57 mmol)
出典と根拠
- ORDレコード
- ord-a7e61bb52da04aeb97d2f2e8f4e6d445
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08987503B2
反応ノート
読み込み中…