Hydrogen Peroxide → 2,3-Epoxy-2-methyl-1,4-naphthoquinone

HRID 879020

反応式

HRID 879020 の反応式
[CH3:1][C:2]1[C:12](=[O:13])[C:11]2[CH:10]=[CH:9][CH:8]=[CH:7][C:6]=2[C:4](=[O:5])[CH:3]=1.[OH-:14].[Na+].OO>CO.O>[CH3:1][C:2]12[C:12](=[O:13])[C:11]3[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=3)[C:4](=[O:5])[CH:3]1[O:14]2

参加物

5

反応物 3

HCID 784Hydrogen PeroxideHCID 4055MenadioneHCID 14798Sodium Hydroxide

生成物 1

HCID 858452,3-Epoxy-2-methyl-1,4-naphthoquinone収率 91.5%

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

実験手順

Menadione crystalline (1) (5 g, 29.04 mmol, 1 equivalent) and 2 M NaOH (7.26 mL, 14.52 mmol, 0.5 equivalents) are dissolved in a mixture of methanol/water 4:1 (50 mL) at 0-2° C. After stirring at this temperature for 10 minutes, 35% hydrogen peroxide is added (4.2 mL, 43.56 mmol, 1.5 equivalents). Work-up: after 30 minutes at 0° C. the product is extracted with ethyl ether. The organic phase is dried over Na2SO4 and evaporated under reduced pressure. A whitish powder is obtained (5 g, 26.57 mmol). Yield: 91.5%.

後処理

  1. extractionafter 30 minutes at 0° C. the product is extracted with ethyl ether
  2. dry with materialThe organic phase is dried over Na2SO4
  3. customevaporated under reduced pressure
  4. customA whitish powder is obtained (5 g, 26.57 mmol)

出典と根拠

ORDレコード
ord-a7e61bb52da04aeb97d2f2e8f4e6d445
出典データセット
uspto-grants-2015_03
特許番号
US08987503B2

関連ノート

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