Glutathione → S-Nitrosoglutathione

HRID 879903

反応式

HRID 879903 の反応式
[NH2:1][C@@H:2]([CH2:6][CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][SH:13])=[O:9])[C:3]([OH:5])=[O:4].[N:21]([O-])=[O:22].[Na+]>Cl>[CH2:6]([C@H:2]([NH2:1])[C:3]([OH:5])=[O:4])[CH2:7][C:8]([NH:10][C@H:11]([C:14]([NH:16][CH2:17][C:18]([OH:20])=[O:19])=[O:15])[CH2:12][S:13][N:21]=[O:22])=[O:9]

参加物

4

反応物 2

HCID 124886GlutathioneHCID 23668193Sodium Nitrite

生成物 1

HCID 104858S-Nitrosoglutathione収率 80%

試薬・触媒・溶媒 1

HCID 313Hydrochloric Acid溶媒

実験手順

Briefly, to a stirred ice-cold solution of glutathione (GSH) (154 mg, 0.5 mmol) in 5 ml of 0.2 N HCl was added a portion of NaNO2 (35 mg, 0.5 mmol). This reaction gives GSNO in a high yield of more than 80%. The final red solution was protected from light with aluminum foil and stable in the dark, which allow it to be used directly after synthesis without purification.

出典と根拠

ORDレコード
ord-3ac6cde16d2147d588e8ce949d32b999
出典データセット
uspto-grants-2015_03
特許番号
US08992945B2

関連ノート

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