Sodium Hydroxide → 3-(Pyridin-4-yl)benzoic acid
反応式
[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([O:12]C)=[O:11])=[CH:3][CH:2]=1.[OH-].[Na+]>CO>[N:1]1[CH:6]=[CH:5][C:4]([C:7]2[CH:8]=[C:9]([CH:14]=[CH:15][CH:16]=2)[C:10]([OH:12])=[O:11])=[CH:3][CH:2]=1参加物
4
実験手順
To a solution of methyl 3-(pyridin-4-yl)benzoate (450 mg, 2.1 mmol) in MeOH (5 mL) was added an aqueous solution of NaOH (1.5 mL, 0.4M). The mixture was stirred at room temperature for 2 h. The reaction solution was then concentrated, the residue was next dissolved in water and adjusted pH to 5˜6 with the 2N HCl. After extraction with EtOAc, the organic layers were dried and concentrated to give the product desired (600 mg, Yield 90%). LCMS (m/z): 200.1 (M+1).
後処理
- concentrationThe reaction solution was then concentrated
- dissolutionthe residue was next dissolved in water
- extractionAfter extraction with EtOAc
- customthe organic layers were dried
- concentrationconcentrated
- customto give the product
出典と根拠
- ORDレコード
- ord-c120e66446ae4db2b0a368a2f0f59095
- 出典データセット
- uspto-grants-2015_03
- 特許番号
- US08993555B2
反応ノート
読み込み中…