Sodium Hydroxide → 1-(2-Carboxyethyl)-4-phenylpyrrole-2-carboxylic acid
反応式
[OH-].[Na+].C([O:5][C:6](=[O:25])[CH2:7][CH2:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=2)[CH:11]=[C:10]1[C:20]([O:22]CC)=[O:21])C>C(O)C>[C:6]([CH2:7][CH2:8][N:9]1[CH:13]=[C:12]([C:14]2[CH:15]=[CH:16][CH:17]=[CH:18][CH:19]=2)[CH:11]=[C:10]1[C:20]([OH:22])=[O:21])([OH:25])=[O:5]参加物
4
反応条件
- 温度
- 55 °C
実験手順
10% Aqueous sodium hydroxide solution (20 mL) was added to a stirred solution of ethyl 1-(3-ethoxy-3-oxo-propyl)-4-phenyl-pyrrole-2-carboxylate (2.0 g, 6.35 mmol) in ethanol (20 mL). The reaction mixture was stirred for 2 h at 50-60° C. The ethanol was evaporated in vacuo and then water added to the residue and acidified with 5N HCl to pH 4-5. The precipitated solid was filtered, washed with water and dried in vacuo to afford 1-(2-carboxyethyl)-4-phenyl-pyrrole-2-carboxylic acid (900 mg, 56%) as a solid.