Water → N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide

HRID 880675

反応式

HRID 880675 の反応式
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].C(N(CC)CC)C.[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH2:24])=[C:19]([CH3:25])[CH:18]=1.O>C(#N)C>[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([NH:24][C:4](=[O:5])[CH2:3][C:2]([CH3:8])([CH3:7])[CH3:1])=[C:19]([CH3:25])[CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 815143,3-Dimethylbutanoyl chlorideHCID 905494-Bromo-2,6-xylidine

生成物 1

HCID 59741059N-(4-Bromo-2,6-dimethyl-phenyl)-3,3-dimethyl-butanamide収率 100.1%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

3,3-Dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-bromo-2,6-dimethylphenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture, and the precipitate which formed was collected to give the title compound as a powder (7.46 g, 100% yield).

後処理

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出典と根拠

ORDレコード
ord-e6ba9c488a0c45f598bb6beaa31a5efb
出典データセット
uspto-grants-2015_03
特許番号
US08993593B2

関連ノート

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