Water → 4-Bromo-2-chloro-6-methyl-phenyl-3,3-dimethylbutanamide

HRID 880685ノート

反応式

HRID 880685 の反応式
[CH3:1][C:2]([CH3:8])([CH3:7])[CH2:3][C:4](Cl)=[O:5].C([N:11](CC)CC)C.[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20](N)=[C:19]([Cl:25])[CH:18]=1.O>C(#N)C>[Br:16][C:17]1[CH:22]=[C:21]([CH3:23])[C:20]([CH:3]([C:2]([CH3:8])([CH3:7])[CH3:1])[C:4]([NH2:11])=[O:5])=[C:19]([Cl:25])[CH:18]=1

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 815143,3-Dimethylbutanoyl chlorideHCID 27696264-Bromo-2-chloro-6-methylaniline

生成物 1

HCID 866496314-Bromo-2-chloro-6-methyl-phenyl-3,3-dimethylbutanamide収率 100%

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

3,3-dimethylbutanoyl chloride (3.37 g, 3.5 mL, 25 mmol) and triethylamine (2.53 g, 3.5 mL, 25 mmol) were added to a solution of 4-Bromo-2-chloro-6-methyl-phenylamine (5.0 g, 25 mmol) in acetonitrile (30 mL). The reaction mixture was stirred at room temperature for 4 hours. Water was added to the mixture and the precipitate formed collected to give the title compound as a powder (7.46 g, 100% yield).

後処理

  1. customthe precipitate formed
  2. customcollected

出典と根拠

ORDレコード
ord-25388dc32b924dec8da47a73d008bc12
出典データセット
uspto-grants-2015_03
特許番号
US08993593B2

反応ノート

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