Potassium Carbonate → 1-(2-Methoxyethyl)piperidin-4-one

HRID 881476

反応式

HRID 881476 の反応式
Cl.O.[NH:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1.[CH3:10][O:11][CH2:12][CH2:13]Br.C([O-])([O-])=O.[K+].[K+]>C(#N)C>[CH3:10][O:11][CH2:12][CH2:13][N:3]1[CH2:8][CH2:7][C:6](=[O:9])[CH2:5][CH2:4]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 809722-Bromoethyl methyl etherHCID 2723901Piperonylamine

生成物 1

HCID 247102641-(2-Methoxyethyl)piperidin-4-one

試薬・触媒・溶媒 1

HCID 6342Acetonitrile溶媒

実験手順

To a solution of 4-piperidone monohydrate hydrochloride salt (2.2 g, 14.32 mmol, 1 eq) in acetonitrile, 2-bromoethyl methyl ether (5.9 ml, 28.6 mmol, 2 eq), and K2CO3 (2 eq) was added and heated at reflux overnight. Reaction extracted into dichloromethane (50 ml), washed with water (2×50 ml), dried (MgSO4), and evaporated in vacuo to give 1-(2-methoxy-ethyl)piperidin-4-one as a yellow oil.

後処理

  1. temperatureheated
  2. temperatureat reflux overnight
  3. customReaction
  4. extractionextracted into dichloromethane (50 ml)
  5. washwashed with water (2×50 ml)
  6. dry with materialdried (MgSO4)
  7. customevaporated in vacuo

出典と根拠

ORDレコード
ord-ddc232511d12427ba046ff4028359b20
出典データセット
uspto-grants-2015_03
特許番号
US08993563B2

関連ノート

読み込み中…