Diethyl Ether → HCID 578074、化合物

HRID 882553ノート

反応式

HRID 882553 の反応式
[Si:1]([CH3:5])([CH3:4])(Cl)Cl.[C:6]([Li])#[C:7][CH3:8].CCOCC.[NH4+].[Cl-].[CH2:17]1[CH2:21]OC[CH2:18]1>>[CH3:4][Si:1]([CH3:5])([C:18]#[C:17][CH3:21])[C:6]#[C:7][CH3:8]

参加物

6

反応物 5

HCID 3283Diethyl EtherHCID 6398DichlorodimethylsilaneHCID 8028TetrahydrofuranHCID 25517Ammonium ChlorideHCID 178506788HCID 178506788、化合物

生成物 1

HCID 578074HCID 578074、化合物

実験手順

To a well stirred solution of (CH3)2SiCl2 (150 mg, 1.2 mmol) in THF (5 mL), propynyl lithium (140 mg, 3 mmol) was added and continued stirring for 4 h at room temperature. The reaction mixture was then treated with Et2O-aq. NH4Cl solution. The organic layer was separated and dried over anhydrous Na2SO4. The yellow liquid so obtained was chromatographed over silica gel using hexane. The dimethyldipropynyl silane was obtained as a colorless liquid in quantitative yields.

後処理

  1. customThe organic layer was separated
  2. dry with materialdried over anhydrous Na2SO4
  3. customThe yellow liquid so obtained
  4. customwas chromatographed over silica gel

出典と根拠

ORDレコード
ord-baa7a234aab24893a88c9a5bc79402a1
出典データセット
uspto-grants-2015_03
特許番号
US08993804B2

反応ノート

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