Hydrazine hydrate (1:1) → HCID 86656622、化合物
反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]参加物
5
実験手順
A mixture of [(R)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (1.2 g, 3.61 mmol) and hydrazine monohydrate (1.0 mL, 20.6 mmol) in EtOH (25 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is removed by filtration and washed with DCM. The filtrate is concentrated in vacuo to afford the title compound as white solid that is used without further purification.
後処理
- customThe precipitated solid is removed by filtration
- washwashed with DCM
- concentrationThe filtrate is concentrated in vacuo
出典と根拠
- ORDレコード
- ord-6a54d8b8460a4f38b414beb8347ad849
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08236808B2
反応ノート
読み込み中…