Hydrazine hydrate (1:1) → ((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

HRID 882903ノート

反応式

HRID 882903 の反応式
[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][N:13]1C(=O)C2C(=CC=CC=2)C1=O)[CH2:9][CH2:10][CH3:11])([CH3:4])([CH3:3])[CH3:2].O.NN>CCO.C(Cl)Cl>[C:1]([O:5][C:6](=[O:24])[NH:7][C@H:8]([CH2:12][NH2:13])[CH2:9][CH2:10][CH3:11])([CH3:2])([CH3:3])[CH3:4]

参加物

5

反応物 2

HCID 24654Hydrazine hydrate (1:1)HCID 66917015[(S)-1-(1,3-Dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester

生成物 1

HCID 86651886((S)-1-Aminomethyl-butyl)-carbamic acid tert-butyl ester

試薬・触媒・溶媒 2

HCID 702Ethanol溶媒HCID 6344Dichloromethane溶媒

実験手順

A mixture of [(S)-1-(1,3-dioxo-1,3-dihydro-isoindol-2-ylmethyl)-butyl]-carbamic acid tert-butyl ester (2.80 g, 8.42 mmol) and hydrazine monohydrate (3.0 mL, 60.0 mmol) in EtOH (50 mL) and DCM (75 mL) is stirred at RT for 48 h. The precipitated solid is collected by filtration and washed with DCM to afford the crude product as a white solid that is used without further purification.

後処理

  1. filtrationThe precipitated solid is collected by filtration
  2. washwashed with DCM

出典と根拠

ORDレコード
ord-8862f306594549be89bdcbf586b9862e
出典データセット
uspto-grants-2012_08
特許番号
US08236808B2

反応ノート

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