Triethylamine → 2-Chloro-1-ethoxy-4-isocyanatobenzene

HRID 882921ノート

反応式

HRID 882921 の反応式
C(N(CC)CC)C.[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([NH2:17])=[CH:13][C:12]=1[Cl:18])[CH3:9].Cl[C:20](Cl)([O:22]C(=O)OC(Cl)(Cl)Cl)Cl>CCOC(C)=O>[CH2:8]([O:10][C:11]1[CH:16]=[CH:15][C:14]([N:17]=[C:20]=[O:22])=[CH:13][C:12]=1[Cl:18])[CH3:9]

参加物

5

反応物 3

HCID 8471TriethylamineHCID 94429TriphosgeneHCID 127487363-Chloro-4-ethoxyaniline

生成物 1

HCID 30159672-Chloro-1-ethoxy-4-isocyanatobenzene

試薬・触媒・溶媒 1

HCID 8857Ethyl Acetate溶媒

実験手順

1-Ethoxy-2-chloro-4-isocyanato-benzene is prepared by addition of triethylamine to a solution of 4-ethoxy-3-chlorophenylamine in EtOAc at 0-5° C. Triphosgene is added and the reaction mixture is slowly heated to reflux over 2 h. The solvent is removed in vacuo and the crude product is filtered through silica to afford the title compound.

後処理

  1. temperaturethe reaction mixture is slowly heated
  2. temperatureto reflux over 2 h
  3. customThe solvent is removed in vacuo
  4. filtrationthe crude product is filtered through silica

出典と根拠

ORDレコード
ord-ae35c798b7ed4080a800857f520a5976
出典データセット
uspto-grants-2012_08
特許番号
US08236808B2

反応ノート

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