benzyl 3-aminosulfonyl-2(R)-methylpropionate → 3-aminosulfonyl-2(R)-methylpropionic acid

HRID 8830ノート

反応式

HRID 8830 の反応式
[NH2:1][S:2]([CH2:5][C@H:6]([CH3:17])[C:7]([O:9]CC1C=CC=CC=1)=[O:8])(=[O:4])=[O:3]>CO.[Pd]>[NH2:1][S:2]([CH2:5][C@H:6]([CH3:17])[C:7]([OH:9])=[O:8])(=[O:4])=[O:3]

参加物

4

反応物 1

HCID 18738444benzyl 3-aminosulfonyl-2(R)-methylpropionate

生成物 1

HCID 187384353-aminosulfonyl-2(R)-methylpropionic acid収率 97.9%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A 100 mL Fisher/Porter vessel was charged with 1.1 g of crude benzyl 3-aminosulfonyl-2(R)-methylpropionate in 35 mL MeOH and a catalytic amount of 10% Pd—C. The mixture was hydrogenated at 50 psi for 24 hours, filtered through Celite and concentrated in vacuo to yield 700 mg of 3-aminosulfonyl-2(R)-methylpropionic acid as a clear oil. The crude acid was used without further purification.

後処理

  1. filtrationfiltered through Celite
  2. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-201cd0be739148328f976d03ae2a2f3d
出典データセット
uspto-grants-2006_08
特許番号
US07091219B2

反応ノート

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