Dimethylformamide → tert-butyl [5-chloro-1'-[(5-methyl-3-phenylisoxazol-4-yl)methyl]-2,2'-dioxospiro[indole-3,3'-pyrrolidin]-1(2H)-yl]acetate

反応式

[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][C:13](=O)[NH:12][CH2:11]3)[C:9](=[O:16])[N:8]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:23])[CH3:22])=[O:19])[C:5]2=[CH:6][CH:7]=1.[H-].[Na+].Br[CH2:28][C:29]1[C:30]([C:35]2[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=2)=[N:31][O:32][C:33]=1[CH3:34].CN(C=[O:45])C>C(OCC)(=O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:10]3([CH2:14][CH2:13][N:12]([CH2:28][C:29]4[C:30]([C:35]5[CH:40]=[CH:39][CH:38]=[CH:37][CH:36]=5)=[N:31][O:32][C:33]=4[CH3:34])[C:11]3=[O:45])[C:9](=[O:16])[N:8]([CH2:17][C:18]([O:20][C:21]([CH3:24])([CH3:22])[CH3:23])=[O:19])[C:5]2=[CH:6][CH:7]=1