Trifluoroacetic acid → 4-(3-Fluorophenoxy)piperidine

HRID 883769

反応式

HRID 883769 の反応式
[F:1][C:2]1[CH:3]=[C:4]([O:8][CH:9]2[CH2:14][CH2:13][N:12](C(OC(C)(C)C)=O)[CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1.C(O)(C(F)(F)F)=O>C(Cl)Cl>[F:1][C:2]1[CH:3]=[C:4]([O:8][CH:9]2[CH2:14][CH2:13][NH:12][CH2:11][CH2:10]2)[CH:5]=[CH:6][CH:7]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 57699520Tert-butyl 4-(3-fluorophenoxy)piperidine-1-carboxylate

生成物 1

HCID 185240024-(3-Fluorophenoxy)piperidine収率 111.8%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of 1,1-dimethylethyl 4-[(3-fluorophenyl)oxy]-1-piperidinecarboxylate (D11) (16.4 g, 55 mmol) in DCM (200 ml) at 0° C. was treated with TFA (17 ml). The reaction was warmed to room temperature and stirred overnight. The solvent was then removed in vacuo and the residue partitioned between DCM and 2M NaOH solution. The aqueous was further extracted with DCM (×2) and the combined organics concentrated in vacuo. The residue was re-dissolved in DCM and extracted with 2M HCl (×2) which was then basified with 2M NaOH and re-extracted with DCM (×3). The combined organics were concentrated in vacuo to give the title compound (12 g). δH (CDCl3, 250 MHz) 1.66 (2H, m), 2.01 (2H, m), 2.73 (2H, m), 3.14 (2H, m), 4.34 (1H, m), 6.68 (3H, m), 7.19 (1H, m), MS (ES): MH+ 196. This whole was diluted with MeOH and treated with 1M HCl in Et2O to give the hydrochloride salt of the title compound (8.0 g).

後処理

  1. customThe solvent was then removed in vacuo
  2. customthe residue partitioned between DCM and 2M NaOH solution
  3. extractionThe aqueous was further extracted with DCM (×2)
  4. concentrationthe combined organics concentrated in vacuo
  5. dissolutionThe residue was re-dissolved in DCM
  6. extractionextracted with 2M HCl (×2) which
  7. extractionre-extracted with DCM (×3)
  8. concentrationThe combined organics were concentrated in vacuo

出典と根拠

ORDレコード
ord-7514a1f03c6a428b9e0c719161b8d403
出典データセット
uspto-grants-2012_08
特許番号
US08236953B2

関連ノート

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