Ethyl Acetate → 2-Amino-2-methylpropyl di-tert-butyl phosphate
反応式
[C:1]([O:5][P:6]([O:13][CH2:14][C:15]([NH:18]C(=O)OCC1C=CC=CC=1)([CH3:17])[CH3:16])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])=[O:7])([CH3:4])([CH3:3])[CH3:2].C(OCC)(=O)C.[H][H]>[OH-].[OH-].[Pd+2].CO>[P:6]([O:5][C:1]([CH3:4])([CH3:3])[CH3:2])([O:8][C:9]([CH3:12])([CH3:11])[CH3:10])([O:13][CH2:14][C:15]([NH2:18])([CH3:17])[CH3:16])=[O:7]参加物
6
実験手順
The product of Example 95B (0.40 g, 0.96 mmol) and 20% palladium hydroxide on carbon (0.21 g) in a ethyl acetate (10 mL) and methanol (1 mL) was stirred under a an atmosphere of hydrogen for 0.5 hours. The reaction was filtered through a bed of celite and concentrate to give the title product (0.256 g).
後処理
- filtrationThe reaction was filtered through a bed of celite
- concentrationconcentrate
出典と根拠
- ORDレコード
- ord-d2caa09872094c2db9006585af748727
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08236950B2
反応ノート
読み込み中…