Hydrochloric Acid → 3-Iodopyridine-4-carboxylic acid

HRID 884936

反応式

HRID 884936 の反応式
[OH-].[Na+].C[O:4][C:5](=[O:13])[C:6]1[CH:11]=[CH:10][N:9]=[CH:8][C:7]=1[I:12].Cl>O>[I:12][C:7]1[CH:8]=[N:9][CH:10]=[CH:11][C:6]=1[C:5]([OH:13])=[O:4]

参加物

5

反応物 3

HCID 313Hydrochloric AcidHCID 14798Sodium HydroxideHCID 2762504Methyl 3-iodopyridine-4-carboxylate

生成物 1

HCID 6192753-Iodopyridine-4-carboxylic acid収率 94.4%

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
60 °C

実験手順

Water was added to 3.20 g of sodium hydroxide to make 30 ml of aqueous solution in total. To the solution, 5.83 g of 3-iodo-isonicotinic acid methyl ester (U.S. Pat. No. 6,277,871B1, O'Conner et al.) was added. The mixture solution was stirred while heating at 60° C. for three hours. The reaction mixture was cooled in ice, to which concentrated hydrochloric acid was added to adjust pH to 2-3. Precipitates were collected by filtration and dried under reduced pressure to give 5.21 g of 3-iodo-isonicotinic acid.

後処理

  1. addition6,277,871B1, O'Conner et al.) was added
  2. additionwas added
  3. customPrecipitates
  4. filtrationwere collected by filtration
  5. customdried under reduced pressure

出典と根拠

ORDレコード
ord-1d711e2cd668462296c2a56d85cd90c6
出典データセット
uspto-grants-2012_08
特許番号
US08242133B2

関連ノート

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