HCID 86651064、化合物 → 2-Amino-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenol

HRID 884946ノート

反応式

HRID 884946 の反応式
[F:1][C:2]([F:20])([F:19])[C:3]([F:18])([C:8]1[CH:13]=[CH:12][C:11]([OH:14])=[C:10]([N+:15]([O-])=O)[CH:9]=1)[C:4]([F:7])([F:6])[F:5].[H][H]>[Pd].C(OCC)(=O)C>[NH2:15][C:10]1[CH:9]=[C:8]([C:3]([F:18])([C:2]([F:1])([F:19])[F:20])[C:4]([F:5])([F:6])[F:7])[CH:13]=[CH:12][C:11]=1[OH:14]

参加物

5

反応物 2

HCID 86651064HCID 86651064、化合物HCID 178418361HCID 178418361、化合物

生成物 1

HCID 866510652-Amino-4-(1,1,1,2,3,3,3-heptafluoropropan-2-yl)phenol収率 78.1%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 2.95 g of 4-(heptafluoroisopropyl)-2-nitrophenol, 20 ml of ethyl acetate and 0.30 g of 5% palladium on carbon was stirred in a hydrogen atmosphere at room temperature for four hours. The reaction mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 2.08 g of 2-amino-4-(heptafluoroisopropyl)phenol.

後処理

  1. filtrationThe reaction mixture was filtered through Celite™
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-720a38ae73b4443c9de9b5aa77b8646d
出典データセット
uspto-grants-2012_08
特許番号
US08242133B2

反応ノート

読み込み中…