2-Chloro-6-nitro-4-(trifluoromethyl)phenol → 2-Amino-6-chloro-4-(trifluoromethyl)phenol
反応式
[Cl:1][C:2]1[CH:7]=[C:6]([C:8]([F:11])([F:10])[F:9])[CH:5]=[C:4]([N+:12]([O-])=O)[C:3]=1[OH:15].[H][H]>[Pd].C(OCC)(=O)C>[NH2:12][C:4]1[CH:5]=[C:6]([C:8]([F:9])([F:10])[F:11])[CH:7]=[C:2]([Cl:1])[C:3]=1[OH:15]参加物
5
実験手順
A mixture of 5.01 g of a mixture containing 2-chloro-4-(trifluoromethyl)-6-nitrophenol, 15 ml of ethyl acetate and 1.0 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for 15 hours. The mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure. The residue was subjected to silica gel column chromatography to give 2.78 g of 2-amino-6-chloro-4-(trifluoromethyl)phenol.
後処理
- filtrationThe mixture was filtered through Celite™
- concentrationThe filtrate was concentrated under reduced pressure
出典と根拠
- ORDレコード
- ord-99298604288a443fa7c9dd95876ca572
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08242133B2
反応ノート
読み込み中…