2-Nitro-4-(trifluoromethoxy)phenol → 2-Amino-4-(trifluoromethoxy)phenol

HRID 884951

反応式

HRID 884951 の反応式
[F:1][C:2]([F:15])([F:14])[O:3][C:4]1[CH:9]=[CH:8][C:7]([OH:10])=[C:6]([N+:11]([O-])=O)[CH:5]=1.[H][H]>[Pd].C(OCC)(=O)C>[NH2:11][C:6]1[CH:5]=[C:4]([O:3][C:2]([F:1])([F:14])[F:15])[CH:9]=[CH:8][C:7]=1[OH:10]

参加物

5

反応物 2

HCID 27757752-Nitro-4-(trifluoromethoxy)phenolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 27377292-Amino-4-(trifluoromethoxy)phenol収率 100%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 8857Ethyl Acetate溶媒

実験手順

A mixture of 4.53 g of 4-trifluoromethoxy-2-nitrophenol, 35 ml of ethyl acetate and 1.0 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for 1.7 hours. The mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure to give 3.92 g of 2-amino-4-trifluoromethoxy phenol.

後処理

  1. filtrationThe mixture was filtered through Celite™
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-0ea26df9fb9049beb4359c0ae80fc46e
出典データセット
uspto-grants-2012_08
特許番号
US08242133B2

関連ノート

読み込み中…