HCID 178418361、化合物 → 3-Amino-5-(trifluoromethyl)-1,2-dihydropyridin-2-one

HRID 884984ノート

反応式

HRID 884984 の反応式
[OH:1][C:2]1[C:7]([N+:8]([O-])=O)=[CH:6][C:5]([C:11]([F:14])([F:13])[F:12])=[CH:4][N:3]=1.[H][H]>[Pd].CO>[NH2:8][C:7]1[C:2]([OH:1])=[N:3][CH:4]=[C:5]([C:11]([F:14])([F:12])[F:13])[CH:6]=1

参加物

5

反応物 2

HCID 178418361HCID 178418361、化合物HCID 178526653HCID 178526653、化合物

生成物 1

HCID 23157873-Amino-5-(trifluoromethyl)-1,2-dihydropyridin-2-one収率 99.3%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

A mixture of 3.13 g of 2-hydroxy-3-nitro-5-trifluoromethylpyridine, 40 ml of methanol and 0.85 g of 5% palladium on carbon was stirred under about one atmosphere of hydrogen at room temperature for two hours. The reaction mixture was filtered through Celite™. The filtrate was concentrated under reduced pressure to give 2.66 g of 3-amino-2-hydroxy-5-trifluoromethylpyridine.

後処理

  1. filtrationThe reaction mixture was filtered through Celite™
  2. concentrationThe filtrate was concentrated under reduced pressure

出典と根拠

ORDレコード
ord-c5aa95dbbd68471cb46461c65ab3c1d7
出典データセット
uspto-grants-2012_08
特許番号
US08242133B2

反応ノート

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