2-(3-Methoxyphenyl)propanoic acid → 2-(3-Hydroxyphenyl)propionic acid, (+-)-

HRID 885257ノート

反応式

HRID 885257 の反応式
C[O:2][C:3]1[CH:4]=[C:5]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1>Br.C(O)(=O)C>[OH:2][C:3]1[CH:4]=[C:5]([CH:9]([CH3:13])[C:10]([OH:12])=[O:11])[CH:6]=[CH:7][CH:8]=1

参加物

4

反応物 1

HCID 5854292-(3-Methoxyphenyl)propanoic acid

生成物 1

HCID 124468532-(3-Hydroxyphenyl)propionic acid, (+-)-

試薬・触媒・溶媒 2

HCID 176Acetic Acid溶媒HCID 260Hydrogen Bromide溶媒

反応条件

温度
100 °C

実験手順

2-(3-Methoxy-phenyl)-propionic acid (0.1 g, 0.55 mmol) was dissolved in a mixture of hydrogen bromide (2 mL) and acetic acid (2 mL) and heated to 100° C. overnight. The mixture was partitioned between H2O and EtOAc, and the aqueous layer was extracted with EtOAc. The combined organic layers were washed with brine, dried over MgSO4, filtered, and concentrated to give the desired product.

後処理

  1. customThe mixture was partitioned between H2O and EtOAc
  2. extractionthe aqueous layer was extracted with EtOAc
  3. washThe combined organic layers were washed with brine
  4. dry with materialdried over MgSO4
  5. filtrationfiltered
  6. concentrationconcentrated

出典と根拠

ORDレコード
ord-009e52aca744482aaee07a56988fc909
出典データセット
uspto-grants-2012_08
特許番号
US08242145B2

反応ノート

読み込み中…