Sodium borohydride → [5-(4-Bromo-2-hydroxymethyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester
反応式
[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH:20]=[O:21])[CH:9]=[CH:8][C:7]=1[Cl:22])[CH3:2].[BH4-].[Na+]>CO>[CH2:1]([O:3][C:4](=[O:23])[CH2:5][C:6]1[CH:11]=[C:10]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20][OH:21])[CH:9]=[CH:8][C:7]=1[Cl:22])[CH3:2]参加物
4
実験手順
To [5-(4-bromo-2-formyl-phenoxy)-2-chloro-phenyl]-acetic acid ethyl ester (0.3 g, 0.76 mmol) in MeOH (20 mL) was added sodium borohydride (0.03 g, 0.78 mmol), and the mixture was stirred at room temperature for 10 minutes. The mixture was worked-up to give the desired product (0.3 g).
出典と根拠
- ORDレコード
- ord-d5ea3a48f0ae4068b5f8a59bf610fcec
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08242145B2
反応ノート
読み込み中…