Hydrochloric Acid → [3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

HRID 885402ノート

反応式

HRID 885402 の反応式
[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:21])([F:20])[F:19])=[CH:14][C:13]=2[CH:22](OC)[O:23]C)[CH:6]=1.Cl>C1COCC1>[CH3:1][O:2][C:3](=[O:27])[CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([O:11][C:12]2[CH:17]=[CH:16][C:15]([C:18]([F:19])([F:21])[F:20])=[CH:14][C:13]=2[CH:22]=[O:23])[CH:6]=1

参加物

4

反応物 2

HCID 313Hydrochloric Acid2 回HCID 58237632[3-(2-Dimethoxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester

生成物 1

HCID 58237636[3-(2-Formyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester収率 113.3%

試薬・触媒・溶媒 1

HCID 8028Tetrahydrofuran溶媒

反応条件

温度
70 °C

実験手順

To [3-(2-dimethoxymethyl-4-trifluoromethyl-phenoxy)-phenyl]-acetic acid methyl ester (0.479 g, 1.2 mmol) in THF (4 mL) was added hydrogen chloride (4N in 1,4-dioxane; 1.5 mL), and the reaction was stirred at 70° C. for 1.5 hours. Additional HCl (0.5 mL) was added, and the reaction was stirred for 40 minutes at 70° C. The mixture was partitioned between H2O and EtOAc, and the aqueous layer was extracted twice with EtOAc. The combined organic layers were dried and concentrated to give the desired product (0.46 g).

後処理

  1. stirringthe reaction was stirred for 40 minutes at 70° C
  2. customThe mixture was partitioned between H2O and EtOAc
  3. extractionthe aqueous layer was extracted twice with EtOAc
  4. customThe combined organic layers were dried
  5. concentrationconcentrated

出典と根拠

ORDレコード
ord-8013f8796dd7464b96e513ef9d2267fd
出典データセット
uspto-grants-2012_08
特許番号
US08242145B2

反応ノート

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