(S)-2-Azido-indan-1-ol → (S)-2-Amino-indan-1-ol

HRID 885408ノート

反応式

HRID 885408 の反応式
[N:1]([CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C@@H:5]1[OH:13])=[N+]=[N-]>CCO.[Pd]>[NH2:1][CH:4]1[CH2:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[C@@H:5]1[OH:13]

参加物

4

反応物 1

HCID 58237515(S)-2-Azido-indan-1-ol

生成物 1

HCID 53893097(S)-2-Amino-indan-1-ol

試薬・触媒・溶媒 2

HCID 23938Palladium触媒2 回HCID 702Ethanol溶媒

実験手順

To (S)-2-azido-indan-1-ol (9.39 mmol) in EtOH (45 mL) was added 10% palladium on carbon (0.20 g), and the mixture was stilled under H2 using a Parr apparatus for 4 hours. Analytical LCMS indicated that some starting material was still present, so additional 10% palladium on carbon (0.20 g) was added, and the reaction was stirred overnight under H2 using a Parr apparatus. The mixture was filtered over a pad of Celite and rinsed well with EtOH. The filtrate was concentrated to give the title compound.

後処理

  1. customfor 4 hours
  2. filtrationThe mixture was filtered over a pad of Celite
  3. washrinsed well with EtOH
  4. concentrationThe filtrate was concentrated

出典と根拠

ORDレコード
ord-435314ee9fc94b499a6ddb7ce971ead5
出典データセット
uspto-grants-2012_08
特許番号
US08242145B2

反応ノート

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