Lithium Hydroxide → {3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid
反応式
C([O:3][C:4](=[O:27])[CH2:5][C:6]1[CH:11]=[CH:10][CH:9]=[C:8]([O:12][C:13]2[CH:18]=[CH:17][C:16]([Br:19])=[CH:15][C:14]=2[CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][C:22]2=[O:26])[CH:7]=1)C.[OH-].[Li+]>O1CCOCC1.O>[Br:19][C:16]1[CH:17]=[CH:18][C:13]([O:12][C:8]2[CH:7]=[C:6]([CH2:5][C:4]([OH:27])=[O:3])[CH:11]=[CH:10][CH:9]=2)=[C:14]([CH2:20][N:21]2[CH2:25][CH2:24][CH2:23][C:22]2=[O:26])[CH:15]=1参加物
5
実験手順
{3-[4-Bromo-2-(2-oxo-pyrrolidin-1-ylmethyl)-phenoxy]-phenyl}-acetic acid ethyl ester (0.35 mmol) in 1,4-dioxane and H2O was treated with lithium hydroxide at 50° C. for 30 minutes. The crude material was purified by preparative HPLC to give the title compound.