Trifluoroacetic acid → (R)-6-Amino-2-(4-fluoro-3,5-dimethyl-phenylamino)-hexanoic acid methyl ester
反応式
[CH3:1][O:2][C:3](=[O:27])[C@H:4]([NH:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([F:25])=[C:20]([CH3:26])[CH:19]=1)[CH2:5][CH2:6][CH2:7][CH2:8][NH:9]C(OC(C)(C)C)=O.FC(F)(F)C(O)=O>ClCCl>[CH3:1][O:2][C:3](=[O:27])[C@H:4]([NH:17][C:18]1[CH:23]=[C:22]([CH3:24])[C:21]([F:25])=[C:20]([CH3:26])[CH:19]=1)[CH2:5][CH2:6][CH2:7][CH2:8][NH2:9]参加物
4
実験手順
To a solution of (R)-6-tert-butoxycarbonylamino-2-(4-fluoro-3,5-dimethyl-phenylamino)-hexanoic acid methyl ester (2.000 g, 5.232 mmol) in 10 mL of dichloromethane, was added trifluoroacetic acid (10 mL). After stirring at room temperature for 19 h, the reaction mixture was concentrated under reduced pressure, and dried in vacuum for overnight. The crude product (1.200 g, 81% yield) was used directly in the next step without further purification. LC-MS: tR=4.8 min; m/z 283 (M+H)+.