関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Methylpiperazine | HCID 53167 | — |
| 反応物 | 3-Chloro-5-fluorobenzonitrile | HCID 2734841 | — |
| 溶媒 | Dimethylformamide | HCID 6228 | — |
| 生成物 | 3-Chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile | HCID 59138987 | 65.8% |
反応手順
A mixture of 3-chloro-5-fluoro-benzonitrile (1 g, 6.45 mmol), 1-methyl-piperazine (0.715 ml, 6.45 mmol), and K2CO3 (2.64 g, 19.3 mmol) in DMF (5 ml) was heated to 140° C. for 40 min in a microwave apparatus. The resulting slurry was filtered and the solvent was removed in vacuo to give 1 g of 3-chloro-5-(4-methyl-piperazin-1-yl)-benzonitrile. The crude reaction mixture was used in the next step without any further purification.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US08242175B2 |
|---|
| 出典データセット | uspto-grants-2012_08 |
|---|
| ORD ID | ord-58c40f4ecb7a48bb88aafb20ba0c1bc2 |
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| 出典メモ | uspto-grants-2012_08 |
|---|
