Sodium Hydroxide → L-Lysine

HRID 8859

反応式

HRID 8859 の反応式
Cl.Cl.C([O:6][C:7](=[O:15])[C@H:8]([CH2:10][CH2:11][CH2:12][CH2:13][NH2:14])[NH2:9])CC.[OH-].[Na+]>CO>[NH2:9][C@H:8]([C:7]([OH:15])=[O:6])[CH2:10][CH2:11][CH2:12][CH2:13][NH2:14]

参加物

4

反応物 2

HCID 14798Sodium HydroxideHCID 86587265L-lysine n-propyl ester dihydrochloride

生成物 1

HCID 5962L-Lysine

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

反応条件

温度
110 °C

実験手順

2.62 Grams (10 mmol) of L-lysine n-propyl ester dihydrochloride was dissolved in 2 ml of methanol, and 5 ml of 2 N aqueous sodium hydroxide solution was added thereto to prepare a treating agent solution. An untreated cotton cloth (160 mm×170 mm, 5.0 g) was allowed to uniformly absorb the total amount of the above treating agent solution and then air-dried for an hour and 15 minutes at room temperature. The dried cloth was heat-treated for 20 minutes at 140° C. in a batch type hot air oven (“IPHH-2000”, an inert oven manufactured by Tabaiesbeck Co., Ltd.) and washed with water. It was further washed with 5% aqueous sodium bicarbonate solution and rinsed three times with water and subsequently was washed with 10% aqueous citric acid solution and rinsed three times with water, and finally washed with household washing detergent solution, rinsed with water and air-dried. A part of the cloth was cut and a solution of ninhydrin in butanol was sprayed on it. Thereafter, it was heated for 10 minutes in an oven of 110° C. to cause coloring thereby the presence of the amino acid was confirmed. As a result of determination for the amount of the bonded L-lysine, it was 0.08 mmol based on 1 g of the cloth. The degree of esterfication was 0.013.

後処理

  1. customto prepare a treating agent solution
  2. customto uniformly absorb the total amount of the above treating agent solution
  3. customair-dried for an hour and 15 minutes at room temperature
  4. additionThe dried cloth was heat-treated for 20 minutes at 140° C. in a batch type hot air oven (“IPHH-2000”, an inert oven manufactured by Tabaiesbeck Co., Ltd.)
  5. washwashed with water
  6. washIt was further washed with 5% aqueous sodium bicarbonate solution
  7. washrinsed three times with water
  8. washsubsequently was washed with 10% aqueous citric acid solution
  9. washrinsed three times with water
  10. washfinally washed with household
  11. washwashing detergent solution
  12. washrinsed with water
  13. customair-dried

出典と根拠

ORDレコード
ord-19b3a387dab34adbb5e6b6e4e17962c8
出典データセット
uspto-grants-2006_08
特許番号
US07091221B2

関連ノート

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