2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol → 1,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-

HRID 886695ノート

反応式

HRID 886695 の反応式
[F:1][C:2]([F:17])([F:16])[C:3]([CH2:7][NH:8]CC1C=CC=CC=1)([OH:6])[CH2:4][OH:5]>C(O)C.[OH-].[OH-].[Pd+2]>[NH2:8][CH2:7][C:3]([OH:6])([C:2]([F:17])([F:16])[F:1])[CH2:4][OH:5]

参加物

4

反応物 1

HCID 248097812-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol

生成物 1

HCID 248097501,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-収率 95.2%

試薬・触媒・溶媒 2

HCID 9942167Palladium hydroxide触媒HCID 702Ethanol溶媒

実験手順

A solution of 3,3,3-trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (8.33 g, 33.4 mmol) in ethanol (550 ml) containing palladium hydroxide on carbon (20%, 800 mg) was stirred under an atmosphere of hydrogen for 24 hours. The catalyst was filtered off via a pad of celite and the filtrate was concentrated under reduced pressure, toluene was added and the solution evaporated again under reduced pressure to give the title compound (5.06 g) as an oil.

後処理

  1. filtrationThe catalyst was filtered off via a pad of celite
  2. concentrationthe filtrate was concentrated under reduced pressure, toluene
  3. additionwas added
  4. customthe solution evaporated again under reduced pressure

出典と根拠

ORDレコード
ord-c42b2b1722744161942cd27dc0535e31
出典データセット
uspto-grants-2012_08
特許番号
US08247377B2

反応ノート

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