(S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diol → 1,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-, (2S)-

HRID 886708ノート

反応式

HRID 886708 の反応式
[F:1][C:2]([F:17])([F:16])[C@@:3]([CH2:7][NH:8]CC1C=CC=CC=1)([OH:6])[CH2:4][OH:5].[H][H]>CO.[Pd]>[NH2:8][CH2:7][C@@:3]([OH:6])([C:2]([F:17])([F:16])[F:1])[CH2:4][OH:5]

参加物

5

反応物 2

HCID 59487491(S)-2-(Trifluoromethyl)-3-(benzylamino)propane-1,2-diolHCID 178418361HCID 178418361、化合物

生成物 1

HCID 594874901,2-Propanediol, 2-(aminomethyl)-3,3,3-trifluoro-, (2S)-収率 109.6%

試薬・触媒・溶媒 2

HCID 23938Palladium触媒HCID 887Methanol溶媒

実験手順

(S)-3,3,3-Trifluoro-2-{[(phenylmethyl)amino]methyl}-1,2-propanediol (160 mg) was dissolved in methanol (1.5 ml) and hydrogenated using 10% palladium on carbon as the catalyst and the H-cube (Thales) as the hydrogen source. The solvent was carefully evaporated to give a pinkish volatile oil (112 mg) which by 1H NMR still contained 13% starting material. Therefore this was re-dissolved in methanol (2 ml) and re-hydrogenated using the H-cube. The solvent was evaporated to give the title compound as a pink/brown oil (93 mg).

後処理

  1. customThe solvent was carefully evaporated

出典と根拠

ORDレコード
ord-bbe503b585a74c9e892b0738621e6d6f
出典データセット
uspto-grants-2012_08
特許番号
US08247377B2

反応ノート

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