[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol → 4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde

HRID 886787ノート

反応式

HRID 886787 の反応式
[CH2:1]([NH:3][C:4]1[C:9]([CH2:10][OH:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]>C(Cl)(Cl)Cl.[O-2].[Mn+2]>[CH2:1]([NH:3][C:4]1[C:9]([CH:10]=[O:11])=[C:8]([CH3:12])[N:7]=[C:6]([S:13][CH3:14])[N:5]=1)[CH3:2]

参加物

4

反応物 1

HCID 57606985[4-(Ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol

生成物 1

HCID 576069534-(Ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde収率 93.6%

試薬・触媒・溶媒 2

HCID 160959Manganese oxide触媒2 回HCID 6212Chloroform溶媒

実験手順

To a solution of [4-(ethylamino)-6-methyl-2-(methylthio)pyrimidin-5-yl]methanol (41.0 g) in chloroform (4000 mL) was added manganese oxide (125 g, 1.4 mole) and stirred for 4 h at room temperature. More manganese oxide was added until the disappearance of alcohol compound was observed. The reaction mixture was filtered through Celite and washed with some chloroform and evaporated all organic solvents to give 38 g (92% yield) of 4-(ethylamino)-6-methyl-2-(methylthio)pyrimidine-5-carbaldehyde as a colorless solid, which was used without purification in the next step.

後処理

  1. filtrationThe reaction mixture was filtered through Celite
  2. washwashed with some chloroform
  3. customevaporated all organic solvents

出典と根拠

ORDレコード
ord-be2788b1b3cd44279d34e48ce3ada367
出典データセット
uspto-grants-2012_08
特許番号
US08247408B2

反応ノート

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