Hydrochloric Acid → 3-[4-(Trifluoromethyl)phenyl]but-2-enoic acid
反応式
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6](/[C:9](/[CH3:16])=[CH:10]/[C:11]([O:13]CC)=[O:12])=[CH:5][CH:4]=1.[OH-].[Na+].Cl>CCO.[Cl-].[Na+].O>[F:1][C:2]([F:17])([F:18])[C:3]1[CH:4]=[CH:5][C:6](/[C:9](/[CH3:16])=[CH:10]/[C:11]([OH:13])=[O:12])=[CH:7][CH:8]=1参加物
6
実験手順
The product from Example 142A (3.5 g, 13.5 mmol) in EtOH (80 mL) was treated with aqueous 1M NaOH (40 mL) and stirred for 16 hours at ambient temperature. The reaction mixture was neutralized with 1N HCl (40 mL), diluted with brine, and extracted with diethyl ether to provide the title compound. NMR (CDCl3) 2.60 (s, 3H), 6.82 (s, 1H), 7.58 (d, 2H), 7.65 (d, 2H).
後処理
- extractionextracted with diethyl ether
出典と根拠
- ORDレコード
- ord-1b199a5470974c5faee98aa5c60b5fae
- 出典データセット
- uspto-grants-2012_08
- 特許番号
- US08247413B2
反応ノート
読み込み中…