Trifluoroacetic acid → 4-(Aminomethyl)benzonitrile

HRID 887261ノート

反応式

HRID 887261 の反応式
C(OC([N:8]([CH2:16][C:17]1[CH:22]=[CH:21][C:20]([C:23]#[N:24])=[CH:19][CH:18]=1)C(OC(C)(C)C)=O)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH2:24][CH2:23][C:20]1[CH:21]=[CH:22][C:17]([C:16]#[N:8])=[CH:18][CH:19]=1

参加物

4

反応物 2

HCID 6422Trifluoroacetic acidHCID 3683768Tert-butyl N-[(4-cyanophenyl)methyl]-N-[(2-methylpropan-2-yl)oxycarbonyl]carbamate

生成物 1

HCID 826084-(Aminomethyl)benzonitrile

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

A solution of N,N-bis(tert-butoxycarbonyl)-4-cyanobenzylamine (0.75 g, 2.25 mmol, prepared according to the literature described in Synthetic Communications 4419:28 (1998), in CH2Cl2 (15 mL) was treated with trifluoroacetic acid (8 mL). After stirring at room temperature for 3 hours, the mixture was concentrated under reduced pressure and the residue was azeotroped with diethyl ether.

後処理

  1. concentrationthe mixture was concentrated under reduced pressure
  2. customthe residue was azeotroped with diethyl ether

出典と根拠

ORDレコード
ord-25d9167931af4b95b23a56ba7ae42a65
出典データセット
uspto-grants-2012_08
特許番号
US08247413B2

反応ノート

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